A randomized clinical trial published in JAMA Network Open found that incorporating online group mindfulness sessions into buprenorphine treatment for opioid use disorder (OUD) significantly reduced opioid cravings compared to treatment as usual.
The study, led by Dr. Zev Schuman-Olivier and colleagues from Cambridge Health Alliance and Harvard Medical School, examined the effectiveness of a 24-week virtual mindfulness-based program compared to a standard recovery support group using evidence-based practices. The trial included 196 participants across 16 U.S. states.
The mindfulness-based program showed similar levels of opioid use and anxiety reduction compared to standard best-practice groups but significantly outperformed in reducing self-reported opioid craving (67 percent vs. 44 percent, P<0.001). Study results indicate that mindfulness is a potent treatment option that can help reduce opioid craving during buprenorphine treatment.
“These findings are compelling evidence that trauma-informed mindfulness groups can be offered as an option for people during medication treatment for opioid use disorder,” said Dr. Zev Schuman-Olivier, MD, principal investigator of the study, founding director of the Center for Mindfulness and Compassion, and director of addiction research at Cambridge Health Alliance. “Mindfulness should be strongly considered for patients experiencing residual cravings after starting buprenorphine.”
As one participant reported, “This program helped me learn new techniques that I didn’t even know existed before I began. I still meditate all the time and don’t even need to have any sound on. I just lay down and push away all of my stress. It was well worth every minute I spent there.”
OUD remains a major public health crisis in the U.S., with over 100,000 opioid overdose deaths each year. Medications for opioid use disorder (MOUD), such as buprenorphine, are evidence-based treatments for opioid use disorder (OUD). Opioid craving is a risk factor for relapse for patients receiving MOUD. Experts highlight that further research is needed to explore how mindfulness can be integrated into existing OUD treatment frameworks to improve long-term recovery outcomes.
Reference:
Schuman-Olivier, Z., Goodman, H., Rosansky, J., et al. (2025). Mindfulness training vs. recovery support for opioid use, craving, and anxiety during buprenorphine treatment: A randomized clinical trial. JAMA Network Open, 8(1), e2454950. https://doi.org/10.1001/jamanetworkopen.2024.54950