Dangerous Substance Combinations Infographic

It is important to note that mixing 2 or more substances significantly increases the risk of dangerous or fatal effects. For example, a study done in Florida found that over 90% of opioid overdose deaths in the state included other, non-opioid drugs with an average of 2–3 drugs other than the opioids found at autopsy. (1)




One dangerous combination is opioids and other sedatives like benzodiazepines. According to the National Institute on Drug Abuse (NIDA), more than 30 percent of opioid overdoses also involve benzodiazepines. Benzodiazepines are commonly prescribed for anxiety or insomnia. Some of the most commonly prescribed benzodiazepines include Xanax (alprazolam), Valium (diazepam), and Klonopin (clonazepam). Combining opioids and benzodiazepines is dangerous